CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-IS-0031-0010-10mg | $120 | ||
| VD-IS-0031-0100-100mg | $960 |
Inhibitor JSH-23 (CAS 749886-87-1)
$120.00 – $960.00
Product Specification
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Appearance:
Tan solid.
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CAS Number:
749886-87-1
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Cat.number:
VD-IS-0031
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Formula:
C16H20N2
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MW:
240.34
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Purity:
≥95% by HPLC
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Solubility:
DMSO (10mg/ml).
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Storage:
-20°C. Protect from light.
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Synonyms:
NF-κB Activation Inhibitor II
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Size:
100mg, 10mg
Description
Inhibitor JSH-23 (CAS 749886-87-1) is a cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 μM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-μB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.
1.Shin, H.M., et al. 2004. FEBS Lett. 571, 50.
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