CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-IS-0129-0005-5mg | $30 | ||
| VD-IS-0129-0025-25mg | $100 |
Ruxolitinib (CAS 1092939-17-7)
$30.00 – $100.00
Product Specification
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Appearance:
Not available
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CAS Number:
1092939-17-7
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Cat.number:
VD-IS-0129
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Formula:
C17H18N6.H3PO4
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MW:
404.36
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Purity:
>99%
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Solubility:
DMSO and water.
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Storage:
Not available
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Synonyms:
INCB 018424 phosphate
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Size:
25mg, 5mg
Description
Ruxolitinib (CAS 1092939-17-7) is an orally bioavailable, potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively; selectivity >100 fold for a wide range of other kinases. It acts by blocking the JAK/STAT pathway. Janus kinases (JAKs) are crucial signal transducers for a variety of cytokines, growth factors, and interferons.
1.RA Mesa. IDrugs. 2010, 13(6), 394-403.
2.C Campas-Moya. Ruxolitinib. Drugs Fut. 2010, 35(6), 457.
3.S Verstovsek et al. N. Engl. J. Med. 2010, 363(12), 1117-1127.
4.A Quintas-Cardama et al. Blood 2010, 115(15), 3109-3117.
5.E Apostolidou et al. Clin. Lymp Myel. 2009, 9(Suppl. 3), S340-S345.
6.Q Lin et al. Org. Lett. 2009, 11(9), 1999-2002.
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