CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-GFC-0119-0010-10mg | $70 | ||
| VD-GFC-0119-0050-50mg | $325 |
TX-1918
$70.00 – $325.00
Product Specification
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Appearance:
Light orange solid
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Cat.number:
VD-GFC-0119
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Formula:
C14H12O3
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MW:
228.2
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Purity:
≥95% by HPLC
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Solubility:
DMSO
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Storage:
+2°C to +8°C. Protect from Light. Packaged under inert gas.
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Synonyms:
Chemical name: 2-((3,5-dimethyl-4-hydroxyphenyl)- methylene)-4-cyclopentene-1,3-dione
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Size:
10mg, 50mg
Description
A cell-permeable arylidene-cyclopentenedione derived tyrphostin that acts as a potent inhibitor for eEF2-K (IC50 = 440 nM), while it inhibits other kinases at much higher concentrations (IC50 = 4.4, 44, 44, and 440 M for Src, PKA, PKC, and EGFR-K, respectively). Displays potent antitumor activity (EC50 = 2.07 and 230 M in HepG2 and HCT116 tumor cells, respectively) with greatly reduced mitochondrial- (≥5000-fold) and hepato-toxicity (≥90-fold) when compared with another tyrphostin, AG 17. It is therefore a more promising candidate as a therapeutic agent for cancer treatment.
Hori, H., et al. 2002. Bioorg. Med. Chem. 10, 3257.
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