CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-CCR-0028-0005-5mg | $70 | ||
| VD-CCR-0028-0050-50mg | $550 |
Tyrene CR4 (CAS 1110670-40-0)
$70.00 – $550.00
Product Specification
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Appearance:
Yellow solid
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CAS Number:
1110670-40-0
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Cat.number:
VD-CCR-0028
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Formula:
C19H16N2O3
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MW:
320.34
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Purity:
≥95% by HPLC
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Solubility:
DMSO
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Storage:
-20°C. Protect from light.
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Synonyms:
(E,E)-2-(Benzylaminocarbonyl)-3- (3,4-dihydroxystyryl)acrylonitrile
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Size:
50mg, 5mg
Description
Tyrene CR4 (CAS 1110670-40-0) is a cell-permeable hydroxystryrylacrylonitrile tyrosine kinase inhibitor that displays anti-tumor properties. Potently inhibits the kinase activities of JAK2 and Bcr-Abl (IC50 ~100-600 nM and 500-700 nM, respectively), and displays excellent selectivity over other tyrosine kinases, Btk, Lck, Lyn, Src, Syk and ZAP-70 (IC50>5 μM). Shown to preferentially induce apoptosis in acute lymphoblastic (ALL) and myeloid leukemia cells (AML), while exhibiting little deleterious effect towards normal bone marrow cell differentiation and proliferation. Reported to be much more potent than AG 490 in inducing ALL cells growth arrest (IC50~120 nM vs. 5-25 μM). Its in vivo efficacy in cancer reduction has been successfully demonstrated in NOD-SCID mice engrafted with human Ph+ ALL cells.
1.Demin, P., et al. 2004. Bioorg. Med. Chem. 12, 3019.
2.Grunberger, T., et al. 2003. Blood 102, 4153.
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