CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-CCR-0124-0025-25mg | $100 | ||
| VD-CCR-0124-0100-100mg | $200 |
WR 1065 (CAS 14653-77-1)
$100.00 – $200.00
Product Specification
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Appearance:
White solid.
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CAS Number:
14653-77-1
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Cat.number:
VD-CCR-0124
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Formula:
C5H14N2S.2HCl
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MW:
207.13
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Purity:
>=95%.
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Solubility:
100 mM in water and to 100 mM in DMSO.
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Storage:
-20°C
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Synonyms:
WR1065 , WR-1065
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Size:
100mg, 25mg
Description
WR 1065 (CAS 14653-77-1) is a cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21waf-1 and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase IIα. Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo. Also exhibits broad spectrum antiviral activity in vitro.
1. North et al (2000) Oncogene 19 1206.
2. Pluquet et al (2003) J.Biol.Chem. 278 11879.
3. Walker et al (2009) Enviorn.Mol.Mutagen. 50 460.
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