CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-NP-0070-0005-5mg | $116 | ||
| VD-NP-0070-0050-50mg | $1000 |
Z-FA-FMK (CAS 105637-38-5)
$116.00 – $1,000.00
Product Specification
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Appearance:
White to off-white powder
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CAS Number:
105637-38-5
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Cat.number:
VD-NP-0070
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Formula:
C21H23N2O4F
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MW:
386.42
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Purity:
>=98%
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Solubility:
DMSO or DMF: soluble20 mM
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Storage:
-20 °C. Shipped on dry ice.
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Synonyms:
Z-Phe-Ala fluoromethyl ketone; Z-Phe-Ala-FMK
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Size:
50mg, 5mg
Description
Z-FA-FMK (CAS 105637-38-5) is a cell permeable negative control for FMK-labelled caspase inhibitors. Irreversible inhibitor of cathepsins B, L, and S, and likely cathepsin H, as well as cruzain and papain. Has recently been shown to inhibit effector, but not initator, caspases in vitro, and suppress some forms of apoptosis. Has been used in vivo.
1.Z-FA-fmk inhibits effector caspases but not initiator caspases 8 and 10, and demonstrates that novel anticancer retinoid-related molecules induce apoptosis via the intrinsic pathway.: F. J. Lopez-Hernandez et al.; Mol. Cancer. Ther. 2, 255 (2003).
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